Synthesis and anti-proliferative activity of new E7010 tethered urea congeners as potential tubulin inhibitors and apoptosis inducers

Key Points

• The aim is to develop and evaluate new E7010-derived urea analogues for their ability to inhibit tubulin and induce apoptosis.
• Designed urea analogues by replacing sulfonamides with ureas
• Optimized compounds through aniline trimming
• Tested compounds for anti-proliferative activity against cancer cells
• Identified potent tubulin inhibitors among the newly synthesized urea analogues
• Demonstrated that the analogues effectively induce apoptosis in targeted cells