What question did this study set out to answer?

This research aims to investigate whether cardiac atrophy is a degenerative response or an adaptive process in viable myocardium.

April 1, 1984Circulation ResearchOpen Access

Atrophy reversal and cardiocyte redifferentiation in reloaded cat myocardium.

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Key result

Cardiocyte cross-sectional area and function in unloaded cat myocardium returned to normal after 1 week of reloading, demonstrating reversibility of atrophy.

Population

Adult cats (2-3 kg)

Comparison

Unloading of a single right ventricular… vs Adjacent, intact papillary muscles from the same…

Design

Preclinical

Follow-up

Up to 3 weeks

Authors

ETErik W. ThompsonTranslational Research Institute TMThomas A. MarinoAmerican College of Cardiology CUCornelius E. UbohUniversity of Lagos

Discussion

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Implication

Supports adult myocardial plasticity; leaves open translation to human unloading therapies.

Key Points

This research aims to investigate whether cardiac atrophy is a degenerative response or an adaptive process in viable myocardium.
A discrete portion of cat myocardium was unloaded by severing the chordae tendinae of a right ventricular papillary muscle.
After one week of unloading, the muscle was reloaded by attaching its apex to the ventricular free wall to restore load.
Morphological and functional assessments were conducted to evaluate cardiocyte changes pre- and post-reloading.
Upon unloading, cardiocyte cross-sectional area decreased significantly, along with a loss of mitochondrial and myofibril volume densities.
After one week of reloading, cardiocyte dimensions and ultrastructural organization returned to control levels, with improved contractile function noted after two weeks.
These findings suggest that adult mammalian myocardium can adaptively respond to mechanical load changes.

Structured PICO

Population

Adult cats (2-3 kg)

Intervention

Unloading of a single right ventricular papillary muscle by severing chordae tendinae, followed by reloading via attachment to the ventricular free wall

Comparator

Adjacent, intact papillary muscles from the same right ventricles (paired controls)

Outcome

Cardiocyte cross-sectional area, volume densities of mitochondria and myofibrils, and contractile functionsurrogate

Adult mammalian myocardium demonstrates profound plasticity, with load-induced cellular atrophy and loss of function being fully reversible upon reloading.

Cite This Study

Thompson et al. (1984) studied this question. Cardiocyte cross-sectional area and function in unloaded cat myocardium returned to normal after 1 week of reloading, demonstrating reversibility of atrophy.

synapsesocial.com/papers/6970eb032d1b404414ca79c0 https://doi.org/10.1161/01.res.54.4.367

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Atrophy reversal and cardiocyte redifferentiation in reloaded cat myocardium.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Atrophy reversal and cardiocyte redifferentiation in reloaded cat myocardium.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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