Key result
Cancer survivorship linked to ~242% higher odds of elevated 10-year ASCVD risk.
Why the study?
Cancer survivors have an increased risk of developing and dying from CVD, but whether 10-year ASCVD risk is elevated compared to those without cancer in a nationally representative U.S. sample was unclear.
Does a history of cancer increase the estimated 10-year ASCVD risk in adults without prior CVD?
Does a history of cancer increase the estimated 10-year ASCVD risk in adults without prior CVD?
Cancer survivors have a significantly higher estimated 10-year ASCVD risk compared to the general population, highlighting the importance of cardiovascular risk assessment in cardio-oncology care.
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Captured external expert commentary on this paper, strongest first. Original sources are linked where available.
“Traditional CV risk calculators underestimate the additional risk of cancer in this patient population. Survivors of cancer have increased CV risk, with 2.7-10.5 times higher 10-year ASCVD risk across bladder, kidney, prostate, colorectal, lung, melanoma, or testicular cancers and a 20-30% elevated risk among women with breast or gynecologic cancers.”
Cancer history associated with higher ASCVD risk estimates; hypothesis-generating for cardio-oncology and requires prospective confirmation before practice change.
Zhang et al. (2021) studied this question. Cancer survivors had 3.42 times higher odds of elevated 10-year ASCVD risk compared to those without a cancer history, particularly among specific cancer types.
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