What question did this study set out to answer?

The aim is to compare treatment outcomes and toxicities between concurrent chemoradiotherapy (CCRT) and sequential chemoradiotherapy (SCRT) for LA-NSCLC.

January 22, 2026International Journal of Clinical Oncology and Cancer ResearchOpen Access

Comparison of Outcome and Toxicities of Concurrent Chemo-radiation Versus Sequential Chemo-radiation in Inoperable Locally Advanced Non-small Cell Lung Cancer

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Authors

AKAyesha KhatunRajshahi Medical College MTMousumi TaniaDhaka Medical College and Hospital SKSheikh KabirRajshahi Medical College

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Implication

Quasi-experimental study compares treatment outcomes and toxicities of concurrent versus sequential chemo-radiation in lung cancer patients, suggesting a balance between efficacy and toxicity.

Key Points

The aim is to compare treatment outcomes and toxicities between concurrent chemoradiotherapy (CCRT) and sequential chemoradiotherapy (SCRT) for LA-NSCLC.
Quasi-experimental design comparing two treatment arms: CCRT and SCRT.
66 patients with LA-NSCLC enrolled, divided into two groups of 33.
CCRT included weekly paclitaxel and carboplatin with concurrent radiotherapy; SCRT utilized induction chemotherapy followed by the same radiotherapy regimen.
Outcomes measured included treatment response using RECIST and toxicities rated by CTCAE v5.0.
At 12 weeks, CCRT showed a higher complete response rate (51.5%) compared to SCRT (33.3%).
Overall response rates were higher in CCRT (84.8%) than in SCRT (72.7%).
CCRT was associated with increased acute toxicities, specifically Grade 2-3 esophagitis (30.3% vs. 15.2%) and Grade 2-3 leucopenia (21.3% vs. 12.1%).
Other toxicities between the two arms were comparable and not statistically significant.

Cite This Study

Khatun et al. (2026) studied this question.

synapsesocial.com/papers/6971bd26642b1836717e1cd0 https://doi.org/10.11648/j.ijcocr.20261101.11

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Implication

Quasi-experimental study compares treatment outcomes and toxicities of concurrent versus sequential chemo-radiation in lung cancer patients, suggesting a balance between efficacy and toxicity.

Comparison of Outcome and Toxicities of Concurrent Chemo-radiation Versus Sequential Chemo-radiation in Inoperable Locally Advanced Non-small Cell Lung Cancer

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Implication

Key Points

Cite This Study

Comparison of Outcome and Toxicities of Concurrent Chemo-radiation Versus Sequential Chemo-radiation in Inoperable Locally Advanced Non-small Cell Lung Cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

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