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January 22, 2026BiomedicinesOpen Access

Beyond Amyloid: Targeting Co-Aggregating Proteins and Targeted Degradation Strategies in Alzheimer’s Disease

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Authors

MMMartina MonacoUniversity of GenoaAPAlessandra Macedo PintoUniversity of GenoaMGMassimo GrilliOspedale Policlinico San Martino

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Implication

This perspective examines targeted degradation strategies in Alzheimer’s disease, suggesting new potential treatments.

Key Points

  • The aim is to explore novel strategies targeting co-aggregating proteins in Alzheimer’s disease beyond amyloid-β.
  • Reviewed proteomic evidence for proteins like midkine, pleiotrophin, and clusterin in amyloid plaques.
  • Evaluated targeted protein degradation technologies, including PROTACs and LYTACs.
  • Discussed AI-assisted screening for degrader design and CNS delivery.
  • Outlined integration of TPD with multi-target therapeutic approaches.
  • Identified co-aggregating proteins potentially influencing disease progression.
  • Proposed targeted degradation as a means to eliminate harmful proteins.
  • Suggested combining TPD methods with existing therapies may enhance treatment efficacy.

Cite This Study

Monaco et al. (2026) studied this question.

synapsesocial.com/papers/6971bd4c642b1836717e1f68https://doi.org/10.3390/biomedicines14010216
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