What question did this study set out to answer?

To review recent developments in piperazine derivatives and their applications in various therapeutic areas.

January 22, 2026ChemistryOpenOpen Access

Piperazine Derivatives: A Privileged Scaffold in Modern Synthesis and Medicinal Chemistry

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This review examines piperazine derivatives' effectiveness in drug development, highlighting new synthesis and design approaches.

To review recent developments in piperazine derivatives and their applications in various therapeutic areas.
Analyzed reports from 2014 to 2024 categorizing by therapeutic class and structural modification.
Assessed substitution patterns and their effects on drug properties.
Explored synthetic methods for developing derivatives, including microwave-assisted reactions and machine learning integration.
Identified consistent effects of structural modifications on drug target affinity and selectivity.
Highlighted strong biological activity for several piperazine series in early evaluations.
Outlined reproducible structure-property relationships guiding future design strategies.

Ten et al. (2026) studied this question.

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