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January 22, 2026Chinese MedicineOpen Access

Unraveling the potential mechanisms of Xiaochaihu decoction alleviates metabolic associated fatty liver disease (MAFLD) by integrated transcriptomics, metabolomics, and network pharmacology

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Authors

YZYing ZhongXZXuetao ZhuJLJian-chao Li

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Overview

Reveals how Xiaochaihu decoction alleviates metabolic associated fatty liver disease, suggesting new therapeutic pathways.

Key Points

  • The research aims to explore the effects and mechanisms of Xiaochaihu decoction on metabolic associated fatty liver disease (MAFLD).
  • Characterization of XCHD components using UPLC/MS.
  • Establishment of high-fat diet-induced MAFLD model in mice.
  • Utilization of non-targeted metabolomics and RNA-sequencing.
  • Integration of network pharmacology analyses and molecular biology experiments.
  • XCHD significantly reduced lipid droplets, total cholesterol, and triglyceride levels in MAFLD mice.
  • Non-targeted metabolomics showed a decrease in hepatic lysophospholipid levels.
  • RNA-sequencing highlighted mechanisms related to lipid droplet formation.
  • XCHD decreased PLIN2 and PLIN3 levels both in vivo and in vitro.
  • The PPARγ signaling pathway was identified as a mechanism involved in XCHD's effects.

Cite This Study

Zhong et al. (2026) studied this question.

synapsesocial.com/papers/6971bd90642b1836717e2308https://doi.org/10.1186/s13020-025-01310-y
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