What question did this study set out to answer?

To develop a humanized murine model of metastatic prostate cancer to evaluate immune responses and tumor growth.

January 22, 2026Cancer Research

Abstract B021: Modeling Human Immune Competent Patient-Derived Metastatic Prostate Cancer in Vivo

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Models metastatic prostate cancer in immune competent mice, revealing hormonal influences on tumor growth and immune response.

To develop a humanized murine model of metastatic prostate cancer to evaluate immune responses and tumor growth.
Used humanized NSG-SGM3 mice engrafted with human CD34+ cells.
Assessed metastatic properties via intracardiac injection of two prostate cancer models: adenocarcinoma and neuroendocrine.
Monitored tumor growth with bioluminescent imaging and evaluated immune competence through flow cytometry.
Successfully engrafted human immune cells in mice, showing tumor growth at distant sites.
Notable differences in human macrophage populations in metastatic bone niches compared to immunocompromised controls.
Hormonal influence significantly impacted the immune response in prostate tumors during testosterone deprivation.

Fenimore et al. (2026) studied this question.

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