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This research aims to characterize PCD-related gene signatures as dual-purpose biomarkers for diagnosing and targeting therapy in S. aureus pneumonia.

January 22, 2026PLoS ONEOpen Access

Cell death-related gene signatures as dual-function biomarkers: Early diagnosis and therapeutic targeting in Staphylococcus aureus pneumonia

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Authors

CQCao QingGuangxi Medical University WSWanjuan SunGuangxi Medical University CYChaomian YangGuangxi Medical University

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Implication

Investigation identifies PCD biomarkers for early diagnosis and treatment in pneumonia, suggesting clinical applications.

Key Points

This research aims to characterize PCD-related gene signatures as dual-purpose biomarkers for diagnosing and targeting therapy in S. aureus pneumonia.
Conducted high-throughput RNA sequencing on murine lung tissues infected with S. aureus.
Utilized bioinformatics to identify differentially expressed genes related to programmed cell death.
Employed machine learning algorithms to prioritize biomarkers and establish a risk-prediction nomogram.
Performed transcriptomic profiling on blood samples from pneumonia patients to validate findings.
Identified 71 PCD-related differentially expressed genes with conserved dysregulation across species.
Machine learning highlighted 11 key genes involved in various cell death pathways.
Developed a four-gene diagnostic panel achieving predictive accuracy of AUC = 0.92.
Discovered significant correlations between biomarkers and immune cell infiltration dynamics.

Cite This Study

Qing et al. (2026) studied this question.

synapsesocial.com/papers/6971bdad642b1836717e248d https://doi.org/10.1371/journal.pone.0339560

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Cell death-related gene signatures as dual-function biomarkers: Early diagnosis and therapeutic targeting in Staphylococcus aureus pneumonia

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Key Points

Cite This Study

Cell death-related gene signatures as dual-function biomarkers: Early diagnosis and therapeutic targeting in Staphylococcus aureus pneumonia

Discussion

Member takes

Implication

Key Points

Cite This Study

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