What question did this study set out to answer?

The review aims to analyze microbial metabolites with the potential to inhibit tyrosinase, a key enzyme in melanogenesis.

Potential Bioactive Function of Microbial Metabolites as Inhibitors of Tyrosinase: A Systematic Review

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Systematic review reveals microbial metabolites inhibit tyrosinase, suggesting sustainable alternatives to conventional inhibitors.

The review aims to analyze microbial metabolites with the potential to inhibit tyrosinase, a key enzyme in melanogenesis.
Conducted a systematic review following PRISMA guidelines.
Literature searches in Scopus and Web of Science identified 156 records.
11 studies meeting inclusion criteria were analyzed for microbial tyrosinase inhibitors.
Identified inhibitors include indole derivatives, phenolic acids, peptides, and triterpenoids.
IC50 values ranged from micromolar to milli-molar levels, with specific examples provided.
Promising efficacy and biocompatibility of microbial metabolites as tyrosinase inhibitors were noted.

Barcenas-Giraldo et al. (2026) studied this question.

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