What question did this study set out to answer?

To explore the influence of hollow interiors and surface characteristics on the design of pH-responsive nanocarriers.

Template-assisted synthesis of pH-responsive hollow mesoporous silica nanocarriers: the role of engineered pores and surface characteristics

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Demonstrates pH-responsive behavior in hollow silica nanocarriers, suggesting design implications for smart drug delivery.

To explore the influence of hollow interiors and surface characteristics on the design of pH-responsive nanocarriers.
Synthesis of hollow silica nanoparticles using polystyrene as sacrificial templates.
Controlled hydrolysis of silica precursor to form a mesoporous shell.
Utilization of calcination to remove the sacrificial template and enhance pore structure.
Analysis of adsorption and desorption kinetics of doxorubicin hydrochloride as a model drug.
Hollow silica nanoparticles displayed a specific surface area greater than 195 m² g⁻¹.
Average pore diameter reached approximately 20 nm with an ink-bottle-like mesoporous structure.
Doxorubicin was released four times faster at pH=4.5 than at pH=7.4, indicating pH-responsive behavior.

Gooneh-Farahani et al. (2026) studied this question.

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