ABSTRACT Wound ulceration induces inflammation, delays tissue repair, and may trigger systemic infections, thereby endangering bodily health. Hydrogel films are capable of accelerating wound healing processes. This study fabricated polyvinylpyrrolidone/polycaprolactone (PVP/PCL) nanofiber‐hydrogel membranes via juxtaposed electrospinning, overcoming the limitations of traditional electrospinning techniques. Hydrophilic PVP (15% w/v in ethanol with 0.03% DAS) and hydrophobic PCL (15% w/v in chloroform/ N , N ‐dimethylformamide (CF/DMF) 4:1) were employed, with PVP/PCL ratios precisely regulated. The optimal VC‐8/2 (PVP/PCL = 8:2) exhibited excellent performance, featuring a viscosity of 176.5 cp, a smooth, bead‐free morphology prior to swelling (diameter: 718.22 ± 142.96 nm), and a twisted structure post‐swelling (diameter: 268.71 ± 94.21 nm)—all enabled by optimized solvents and juxtaposed electrospinning that eliminated phase separation. Additionally, the VC‐8/2 demonstrated a tensile strength of 1.16 ± 0.10 MPa, an elongation at break of 94.35% ± 5.64%, and a 40% water absorption rate after 12 h. Attenuated total reflectance Fourier transform infrared spectroscopy (ATR‐FTIR) confirmed the successful cross‐linking of PVP, while CCK‐8 assays revealed high L929 cell viability (87.23%–91.44%), exceeding the 85% non‐cytotoxic threshold. These biocompatible membranes integrate the exudate absorption capacity of PVP and the mechanical support of PCL, rendering them highly promising for advanced wound dressing applications.
Wang et al. (2026) studied this question.