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January 22, 2026Journal of Biomedical Materials Research Part B Applied Biomaterials

Immunomodulation and Oxidative Stress Mitigation Mediate Enhanced Bone Regeneration by a Platelet‐Rich Plasma‐Loaded Composite Scaffold

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Authors

JYJian YangAffiliated Hospital of Southwest Medical UniversityLZLipeng ZhengAffiliated Hospital of Southwest Medical UniversityDFDaxiong FengAffiliated Hospital of Southwest Medical University

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Implication

Demonstrates enhanced bone regeneration in a rabbit model using a composite scaffold with platelet-rich plasma, suggesting new treatment avenues for bone defects.

Key Points

  • The aim is to develop a composite scaffold that combines structural support and bioactivity to improve bone regeneration in critical-sized defects.
  • Developed a PRP-loaded PDA/CS hydrogel integrated into a 3D printed n-HA/PA66 scaffold.
  • Assessed cytoprotective and immunomodulatory effects in vitro using human osteoblasts and other cell types under stress conditions.
  • Validated the scaffold's efficacy in a rabbit femoral condyle model through various imaging and histological techniques.
  • Demonstrated antioxidant activity of the hydrogel, protecting cells from oxidative stress.
  • Enhanced BMSC proliferation and mineralization while promoting M2 macrophage polarization.
  • Significantly improved bone microarchitecture and mineral density as well as upregulated osteogenic markers in vivo.

Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/6971be2c642b1836717e2c54https://doi.org/10.1002/jbmb.70037
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