Reaction Engineering Enables Selective Chemoenzymatic Transformation of Alkynes into α-Bromoketones and 1,2-Dibromostyrenes

Key Points

• The research aims to improve the chemoselectivity in the catalytic synthesis of α-haloketones from alkynes and alkenes.
• Utilized vanadium-dependent chloroperoxidase for selective halogenation
• Explored transformation of alkynes into α-bromoketones and 1,2-dibromostyrenes
• Analyzed the efficiency of the reaction under varying conditions
• Achieved higher chemoselectivity compared to traditional halogenation methods
• Produced α-bromoketones and 1,2-dibromostyrenes in significant yields
• Demonstrated the step- and atom-economy of the process