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January 22, 2026Clinical Hematology InternationalOpen Access

Factor XIII Deficiency: A Review of Biology, Testing, and Treatment

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Authors

JJJ.J. JacobsGBGarrett S. BoothVCVictoria Costa

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Overview

Review explores diagnosis and management of factor XIII deficiency, indicating clinical implications for treatment.

Key Points

  • The aim is to review the molecular biology, clinical features, diagnostic methods, and evidence-based management of factor XIII deficiency.
  • Reviewed molecular biology, epidemiology, and clinical features of FXIII deficiency.
  • Analyzed diagnostic methods including quantitative FXIII activity assays and antigenic phenotyping.
  • Evaluated management strategies like plasma-derived FXIII concentrate and recombinant FXIII-A2.
  • Identified typical symptoms: delayed umbilical stump hemorrhage and recurrent pregnancy loss.
  • Emphasized the importance of tailored perioperative and obstetric care based on activity thresholds.
  • Confirmed the role of recombinant FXIII-A2 for specific genetic defects and not for others.

Cite This Study

Jacobs et al. (2026) studied this question.

synapsesocial.com/papers/6971be50642b1836717e3011https://doi.org/10.46989/001c.155180
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