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August 5, 2025Bleeding Thrombosis and Vascular BiologyOpen Access

PO75 | Prophylaxis with RFXIII: a clinical case in a pediatric patient with congenital FXIII deficiency and delayed diagnosis

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Overview

Case report highlights effective prophylactic rFXIII treatment in pediatric patient, suggesting safety and efficacy in managing bleeding episodes.

Key Points

  • A 6-year-old girl with severe congenital factor XIII deficiency experienced several hematomas and bleeding episodes.
  • Normal coagulation tests complicated the delayed diagnosis until a factor XIII assay revealed a deficiency of 1%.
  • The patient received prophylactic treatment with rFXIII at 35 IU/kg every 4 weeks, leading to resolution of symptoms.
  • Since starting prophylaxis in August 2022, the patient reported only minor bleeding episodes, indicating the treatment's effectiveness.

Cite This Study

A 2025 study studied this question.

synapsesocial.com/papers/689521f09f4f1c896c428722https://doi.org/10.4081/btvb.2025.344
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