Stereodivergent reaction generates unique chiral tetrahydroquinolines from tertiary alcohols, suggesting new pathways in synthesis.
We report herein a highly efficient stereodivergent reaction on racemic quinolinyl-substituted tertiary alcohols via Ir-catalyzed asymmetric transfer hydrogenation, which affords structurally unique chiral 1,2,3,4-tetrahydroquinolines bearing both endo- and exocyclic chirality....
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Haokun et al. (2026) studied this question.
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