What question did this study set out to answer?

Summarize how host-derived factors, diet, and environmental exposures shape gut microbiota composition and evaluate therapeutic strategies to modulate microbial balance.

August 16, 2019PeerJOpen Access

Factors affecting the composition of the gut microbiota, and its modulation

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Authors

NHNihal HasanTongji Hospital HYHongyi YangElectric Power Research Institute

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Implication

Review highlights host, dietary, and environmental drivers of gut microbiota composition, suggesting therapeutic avenues via prebiotics, probiotics, and fecal transplantation.

Key Points

Summarize how host-derived factors, diet, and environmental exposures shape gut microbiota composition and evaluate therapeutic strategies to modulate microbial balance.
Narrative synthesis of mechanisms controlling intestinal microbial ecology, including host physiological secretions, exogenous disruptions, and microbiome-targeted therapeutics.
Host-derived specific factors (such as microRNAs) and nonspecific factors (including antimicrobial peptides, mucus, and immunoglobulin A) actively regulate gut bacterial colonization by selectively promoting or suppressing specific taxa.
Extrinsic pressures including dietary patterns, antibiotic therapy, and chronological aging alter microbial diversity, predisposing hosts to dysbiosis-associated diseases.
Microbial community equilibrium can be therapeutically restored through targeted interventions, specifically prebiotics, probiotics, and fecal microbiota transplantation.

Cite This Study

Hasan et al. (2019) studied this question.

synapsesocial.com/papers/697240a8da50910f9664e745 https://doi.org/10.7717/peerj.7502

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Implication

Review highlights host, dietary, and environmental drivers of gut microbiota composition, suggesting therapeutic avenues via prebiotics, probiotics, and fecal transplantation.

Factors affecting the composition of the gut microbiota, and its modulation

Discussion

Member takes

Implication

Key Points

Cite This Study

Factors affecting the composition of the gut microbiota, and its modulation

Discussion

Member takes

Implication

Key Points

Cite This Study

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