What question did this study set out to answer?

The aim is to characterize outcome domains and definitions used in interventions for perianal fistulising Crohn’s disease.

P0500 Outcome Heterogeneity in Perianal Fistulising Crohn’s Disease: A Systematic Review for the TOpClass Treat-to-Target Initiative

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This systematic review explores outcome definitions in perianal fistulising Crohn’s disease, highlighting the need for standardization.

The aim is to characterize outcome domains and definitions used in interventions for perianal fistulising Crohn’s disease.
Conducted a systematic review updating a previous analysis from 2019.
Reviewed studies published from July 2016 to December 2024.
Searched databases Ovid MEDLINE and EMBASE for relevant studies.
Two independent reviewers screened outcomes and definitions from interventional studies.
Of 1688 studies screened, 67 met inclusion criteria.
91% reported clinical response measures defined by reduced fistula discharge.
51% included radiological outcomes, while 42% covered quality of life measures.
Definitions of clinical remission greatly varied, with 67% defining it as absence of discharge.

Hanna et al. (2026) studied this question.

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