What question did this study set out to answer?

To investigate myocardial alterations in treatment-naive cancer patients using cardiac magnetic resonance imaging.

January 23, 2026Open Access

Myocardial fibrosis and strain impairment in treatment-naïve cancer patients: insights into cancer-related myocardial remodeling from a prospective case–control CMR study

FCFederica CatapanoCardiac Imaging CLCostanza LisiHumanitas University GSGiulio StefaniniHumanitas University

Key Result

Treatment-naive cancer patients show subclinical myocardial fibrosis, indicated by elevated native T1 and reduced global longitudinal strain compared to healthy controls.

Key Points

To investigate myocardial alterations in treatment-naive cancer patients using cardiac magnetic resonance imaging.
Conducted a prospective case-control study with cancer patients and matched controls.
Utilized cardiac magnetic resonance imaging to assess myocardial fibrosis and strain impairment.
Evaluated native T1 values and global longitudinal strain among participants.
Identified elevated native T1 values indicating myocardial fibrosis in cancer patients.
Observed reduced global longitudinal strain, suggesting impaired cardiac function in these individuals.

Structured PICO

Does treatment-naive diffuse large B cell lymphoma cause subclinical myocardial alterations detectable by CMR compared to healthy controls?

Population

100 participants, including 50 treatment-naive cancer patients affected by diffuse large B cell lymphoma (DLBCL) with no prior history of cardiovascular disease and normal LVEF, and 50 age- and gender-matched healthy controls.

Intervention

Cardiac magnetic resonance (CMR) imaging including T1/T2 mapping and strain analysis

Comparator

Age- and gender-matched healthy controls without prior history of cardiovascular disease

Outcome

Differences in myocardial tissue characterization (native T1, T2, ECV) and functional parameters (GLS, GCS, GRS) between treatment-naive DLBCL patients and healthy controlssurrogate

Treatment-naive DLBCL patients exhibit subclinical myocardial alterations characterized by elevated native T1 and reduced GLS, suggesting cancer-related myocardial remodeling precedes cardiotoxic therapy.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

Treatment-naive cancer patients exhibit subclinical myocardial alterations, characterized by elevated native T1 and reduced global longitudinal strain. Cardiac magnetic resonance emerges as a valuable tool for identifying early biomarkers of myocardial dysfunction, offering opportunities for risk stratification and proactive management in cardio-oncology.

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