Abstract Background Home parenteral nutrition (HPN) is a vital therapy for selected inflammatory bowel disease (IBD) patients with intestinal failure. Understanding patient profiles and outcomes can guide optimal care. This study aimed to describe patient characteristics, HPN indications, duration, and factors enabling HPN discontinuation in IBD. Methods All adult IBD patients (Crohn’s disease or ulcerative colitis) treated with HPN between 2005 and 2025 at a tertiary centre were retrospectively reviewed. Only patients who were alive at HPN termination or remained on ongoing HPN were included. Collected data included demographics, indication for HPN (pre-surgical vs. non-pre-surgical), presence of short bowel syndrome, HPN duration, and reason for discontinuation. Results Seventy patients were included (mean age 38.2 ± 14.5 years; 45.7% female); 90% had Crohn’s disease. HPN was discontinued in 42 patients due to: surgery in 22 (52.4%) patients, optimized medical therapy in 16 (38.1%) patients, and other causes in 4 (9.5%) patients. The following table presents HPN duration according to patient subgroups: Conclusion In this 20-year cohort, nearly half of IBD patients initiated HPN in the preoperative setting, with two-thirds of them successfully discontinued therapy after the surgery. The presence of short bowel syndrome was related to a significantly longer duration of HPN. These findings highlight the importance of tailoring expectations and goals in managing HPN in patients with complex IBD. Conflict of interest: Dr. Papier, Irena: No conflict of interest Weisshof, Roni: No conflict of interest Chermesh, Irit: No conflict of interest
Papier et al. (Thu,) studied this question.