What question did this study set out to answer?

The aim is to review and understand IgG4-related prostatitis as a rare manifestation of IgG4-related disease and its implications.

January 23, 2026Clinical and Experimental Rheumatology0 citations

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IgG4-related prostatitis: expanding the spectrum of IgG4-related disease. A systematic review

CPCristina PamfilIuliu Hațieganu University of Medicine and Pharmacy MMMaia Ioana Mihon VSVictor SurduIuliu Hațieganu University of Medicine and Pharmacy

Key Points

The aim is to review and understand IgG4-related prostatitis as a rare manifestation of IgG4-related disease and its implications.
Conducted a systematic review of existing literature on IgG4-related prostatitis.
Assessed the overlap with benign and malignant prostatic disorders.
Examined current management strategies including glucocorticoids and surgery.
Identified IgG4-related prostatitis as likely under-recognised.
Noted that serum IgG4 and PSA levels are unreliable for diagnosis.
Highlighted the need for multicenter studies to define prevalence and optimal management strategies.

Abstract

IgG4-related prostatitis is a rare and likely under-recognised manifestation of IgG4-RD. Its overlap with benign and malignant prostatic disorders delays diagnosis. Serum IgG4 and PSA are unreliable markers of disease and monitoring. Glucocorticoids remain first-line therapy, with surgery in obstructive cases. Multicentre studies are needed to define prevalence, natural history, and optimal management.

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IgG4-related prostatitis: expanding the spectrum of IgG4-related disease. A systematic review

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