What question did this study set out to answer?

To evaluate the Fibrinogen-to-Lymphocyte Ratio as a non-invasive biomarker for assessing disease severity in ulcerative colitis.

January 23, 2026Journal of Crohn s and Colitis

P0357Fibrinogen-to-lymphocyte ratio as a predictor of disease severity in ulcerative colitis

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To evaluate the Fibrinogen-to-Lymphocyte Ratio as a non-invasive biomarker for assessing disease severity in ulcerative colitis.
Cross-sectional observational study at the Inflammatory Bowel Disease Clinic
Assessment of clinical activity using Truelove–Witts criteria
Endoscopic activity evaluated with Mayo endoscopic subscore
Histological activity determined by the Riley score
Statistical analyses including t-test, ANOVA, and ROC analysis
62 patients were included with varied clinical activities reported
FLR did not correlate significantly with clinical activity
Significant association found between FLR and moderate–severe endoscopic activity (p = 0.03)
FLR was significantly associated with histological activity (p = 0.02)
ROC analysis identified FLR >198 as predictive of moderate–severe histological activity (AUC 0.807)

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Implication

Cross-sectional study demonstrates that FLR predicts endoscopic and histological severity in ulcerative colitis, indicating its potential clinical use.

Cite This Study

Romero et al. (2026) studied this question.

synapsesocial.com/papers/69730ed4c8125b09b0d1e96e https://doi.org/10.1093/ecco-jcc/jjaf231.538

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Implication

Cross-sectional study demonstrates that FLR predicts endoscopic and histological severity in ulcerative colitis, indicating its potential clinical use.

P0357Fibrinogen-to-lymphocyte ratio as a predictor of disease severity in ulcerative colitis

Key Points

Discussion

Implication

Cite This Study

P0357Fibrinogen-to-lymphocyte ratio as a predictor of disease severity in ulcerative colitis

Key Points

Discussion

Implication

Cite This Study

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