Proteomic profiling reveals inflammatory pathways in proliferative diabetic retinopathy, highlighting potential therapeutic targets.
Significant differences in proteomic profiles were observed in PDR patients, especially in vitreous samples, with CA family members identified as potential therapeutic targets for PDR. Endotyping analysis of vitreous samples uncovered unique patient population with enriched CCL/CXCL/IL6/IL18 inflammatory pathways, highlighting the significance of local protein signature changes in PDR disease heterogeneity and its potential applications in patient stratification and therapeutic treatment.
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Lv et al. (2026) studied this question.
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