Persistent Seronegativity and Absence of Intact Proviruses Despite Prolonged Initial Viremia in Early-Treated Perinatal HIV Infection

Puntos clave

• To explore the implications of persistent seronegativity and lack of intact proviruses in an adolescent with early-treated perinatal HIV infection.
• Case report of an adolescent with perinatal HIV-1 infection treated from 1 month of age.
• Monitored viremia until age 4, followed by serology assessments at ages 11 and 18.
• Evaluated presence of intact proviruses over time.
• Patient showed persistent viremia until age 4 with negative or weakly reactive serologies since then.
• No intact proviruses were detected at ages 11 and 18, challenging current definitions of HIV persistence and remission.