Effect of High-Dose Oral Insulin in Children With Stage 1 Type 1 Diabetes: The Fr1da Insulin Intervention Randomized Controlled Trial.

Key Points

• To evaluate the effects of high-dose oral insulin on the progression of dysglycemia and diabetes in children with stage 1 Type 1 Diabetes.
• Conducted a randomized controlled trial
• Included children diagnosed with stage 1 Type 1 Diabetes
• Administered high-dose oral insulin for one year
• Monitored for progression to dysglycemia or diabetes and immune response to insulin
• High-dose oral insulin did not affect the progression to dysglycemia
• No significant change in the immune response to insulin over the course of one year