What question did this study set out to answer?

The study investigates how biologic therapies influence macrophage function and phenotype alterations in IBD.

P0053Biologic therapy remodels the immune landscape in IBD leading to altered macrophage phenotypes

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Observational research investigates macrophage changes in IBD patients following biologic therapy, suggesting new treatment potential.

The study investigates how biologic therapies influence macrophage function and phenotype alterations in IBD.
Prospectively recruited patients with IBD undergoing endoscopy.
Collected endoscopic biopsies from the sigmoid colon to generate IBD explants.
Co-cultured IBD explants with IgG control and biologic therapies for 24 hours.
Isolated macrophages from healthy donors and polarized them to M1 or M2 phenotypes.
Analyzed macrophage responses to conditioned media from treated explants using GraphPad Prism.
M0 macrophages showed significant variation in inflammatory markers when exposed to TCM from CD and UC.
M2 macrophages had decreased anti-inflammatory markers upon exposure to VDZ-treated CD TCM but not to UST or IFX-treated TCM.
No significant differences were observed in M1 macrophage markers with UST or IFX-treated TCM.
Decreased TREM1 expression was noted in both M1 and M2 macrophages exposed to VDZ-treated UC TCM.

Corcoran et al. (2026) studied this question.

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