What question did this study set out to answer?

To investigate the association between gastrointestinal microbiome and disease activity in newly diagnosed Crohn's disease patients.

January 23, 2026Journal of Crohn s and Colitis

P0056The gastrointestinal microbiome is associated with endoscopic disease activity in newly-diagnosed Crohn’s Disease: Results from the PROFILE trial

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Authors

GYG YoungNewcastle University NNN NoorUniversity of Cambridge LBL BeckNewcastle University

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Implication

This trial examines the correlation between the microbiome and disease activity in newly diagnosed Crohn’s disease, suggesting significant implications for treatment strategies.

Key Points

To investigate the association between gastrointestinal microbiome and disease activity in newly diagnosed Crohn's disease patients.
Enrolled adults newly diagnosed with Crohn's disease in the PROFILE trial.
Participants received either accelerated step-up or top-down therapy.
Stool samples were collected at baseline and after 48 weeks for metagenomic sequencing.
Uni- and multi-variate statistical methods were used to assess microbiome associations with disease activity measures.
699 stool samples from 456 participants were sequenced, revealing a median microbial read count of 3.8x107 per sample.
Significant improvement in disease activity measures, including stool frequency and abdominal pain, by week 48 (P < 0.05).
Lower microbial richness and diversity correlated with higher stool frequency (P < 0.005) and greater SES-CD scores (P = 0.03).
Microbiome structure associated with stool frequency and Montreal disease behavior scores (P = 0.02, P = 0.05).

Cite This Study

Young et al. (2026) studied this question.

synapsesocial.com/papers/69730ef2c8125b09b0d1ecaa https://doi.org/10.1093/ecco-jcc/jjaf231.237

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Implication

This trial examines the correlation between the microbiome and disease activity in newly diagnosed Crohn’s disease, suggesting significant implications for treatment strategies.

P0056The gastrointestinal microbiome is associated with endoscopic disease activity in newly-diagnosed Crohn’s Disease: Results from the PROFILE trial

Discussion

Member takes

Implication

Key Points

Cite This Study

P0056The gastrointestinal microbiome is associated with endoscopic disease activity in newly-diagnosed Crohn’s Disease: Results from the PROFILE trial

Discussion

Member takes

Implication

Key Points

Cite This Study

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