Synthesis of thieno[2,3-b]indoles by Cloke–Wilson rearrangement of spiro donor–acceptor cyclopropanes

Sk Jubayar Ahashan; Kousik Maji; Syed Ramizul Kabir; Tridev Ghosh

doi:10.1039/d5cc06215b

January 1, 2026Chemical Communications

Synthesis of thieno[2,3-b]indoles by Cloke–Wilson rearrangement of spiro donor–acceptor cyclopropanes

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Key Points

To develop an efficient one-pot synthesis of thieno[2,3-b]indoles using spiro donor–acceptor cyclopropanes.
Utilized Lawesson’s reagent for thiocarbonyl Cloke–Wilson rearrangement
Applied oxidative aromatization under open-air conditions
Employed spiro donor–acceptor cyclopropyl oxindoles as starting materials
Thieno[2,3-b]indoles were synthesized successfully
The reaction proceeded smoothly, indicating a robust method
Produced compounds showed expected structural properties

Implication

One-pot synthesis demonstrates efficient creation of thieno[2,3-b]indoles, suggesting potential for novel compounds.

Abstract

A one-pot synthesis of thieno[2,3-b]indoles is reported via a Lawesson’s reagent-mediated thiocarbonyl Cloke–Wilson rearrangement of spiro donor–acceptor cyclopropyl oxindoles, followed by oxidative aromatization under open-air conditions. The reaction proceeds smoothly...

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Cite This Study

Ahashan et al. (2026) studied this question.

synapsesocial.com/papers/69730f34c8125b09b0d1effb https://doi.org/10.1039/d5cc06215b

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Synthesis of thieno[2,3-b]indoles by Cloke–Wilson rearrangement of spiro donor–acceptor cyclopropanes

Key Points

Implication

Abstract

Discussion

Cite This Study

Synthesis of thieno[2,3-b]indoles by Cloke–Wilson rearrangement of spiro donor–acceptor cyclopropanes

Key Points

Implication

Abstract

Discussion

Cite This Study

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