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This review aims to analyze colectomy rates and associated factors in patients with acute severe ulcerative colitis after medical treatment.

P1241Colectomy Rates and Patient-associated Factors in Acute Severe Ulcerative Colitis: Systematic Review and Pooled Proportion Meta-analysis

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This review aims to analyze colectomy rates and associated factors in patients with acute severe ulcerative colitis after medical treatment.
Conducted a systematic review and meta-analysis according to PRISMA guidelines.
Analyzed data from randomized and non-randomized trials and cohort studies.
Evaluated colectomy rates at various time points: in hospital, 3, 6, and 12 months.
Performed pooled proportion meta-analyses and meta-regression to identify risk factors.
The pooled 12-month colectomy rate was 30.5%, varying significantly by therapy type.
Sequential rescue therapy had the highest rate at 56.8%, followed by cyclosporine and infliximab.
In-hospital colectomy rate was 16.5%, highest with cyclosporine (21.7%).
Meta-regression indicated that older studies had lower colectomy rates, and higher baseline steroid use increased risk.

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Systematic review shows high colectomy rates in acute severe ulcerative colitis, indicating need for better treatments.

Barberio et al. (2026) studied this question.

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