PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
Synapse
⌘+K
Synapse
January 23, 2026npj Biofilms and MicrobiomesOpen Access

Probiotic bacteria Bifidobacterium bifidum upregulation of intestinal epithelial tight junction barrier is mediated by TLR-2/TLR-6 receptor complex activation of occludin gene

View Full Paper
Ask AI
Bookmark
Share

Authors

RARaz AbdulqadirRARana Al–SadiYGYash Gupta

Discussion

Loading...

Member takes

Overview

Investigates the mechanism of Bifidobacterium bifidum enhancing the intestinal barrier in inflammatory bowel disease, suggesting beneficial microbe-host interactions.

Key Points

  • To explore how Bifidobacterium bifidum upregulates the intestinal epithelial tight junction barrier.
  • Used in vitro models (Caco-2 monolayers) and in vivo models (live mice) to study the effects.
  • Measured occludin gene activity and protein expression levels.
  • Evaluated the role of TLR-2/TLR-6 receptor complex activation in the process.
  • Bifidobacterium bifidum upregulated the intestinal tight junction barrier, specifically increasing occludin levels.
  • Knockdown of occludin prevented the enhancement of the tight junction barrier.
  • The mechanism involved TLR-2/TLR-6 activation and IRAK-1 phosphorylation leading to TOLLIP recruitment.

Cite This Study

Abdulqadir et al. (2026) studied this question.

synapsesocial.com/papers/69730f78c8125b09b0d1f450https://doi.org/10.1038/s41522-025-00903-7
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Probiotics and the intestinal tight junction barrier function2025 · 44 citations
  2. 2Bifidobacterium bifidum inhibits the TNF-α induced increase in intestinal epithelial tight junction permeability via a TLR-2/TLR-6 and PPAR-γ dependent inhibition of NF-κB p50/p652024
  3. 3Lactobacillus acidophilus inhibits the TNF-α-induced increase in intestinal epithelial tight junction permeability via a TLR-2 and PI3K-dependent inhibition of NF-κB activation2024 · 70 citations
  4. 4Lactiplantibacillus plantarum ST-III and Lacticaseibacillus rhamnosus KF7 Enhance the Intestinal Epithelial Barrier in a Dual-Environment In Vitro Co-Culture Model2024 · 8 citations
  5. 5Protective Effects of a Bifidobacterium-Based Probiotic Mixture on Gut Inflammation and Barrier Function2025 · 6 citations