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September 10, 2025Microbiology ResearchOpen Access

Protective Effects of a Bifidobacterium-Based Probiotic Mixture on Gut Inflammation and Barrier Function

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In vitro analysis reveals the probiotic mixture reduces gut inflammation and enhances epithelial barrier function.

The probiotic mixture significantly reduced LPS-induced nitric oxide release by 25.9–48.3%, indicating anti-inflammatory effects.
Transepithelial electrical resistance increased by up to 31% at 105 CFU/mL, demonstrating improved epithelial barrier integrity.
The formulation preserved tight junction protein localization, crucial for maintaining gut health and preventing inflammation.
Adhesion to Caco-2 cells was comparable to Lacticaseibacillus rhamnosus GG, underscoring its potential as an effective probiotic.

You et al. (2025) studied this question.

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