Endobronchial ultrasound-guided mediastinal biopsies for the diagnosis of mediastinal diseases: A network meta-analysis

Yong-Jia Qi; Jing Zhang; Esperanza Salcedo Lobera; Qiuyue Song; Ren-Hai Zhong; Konstantina Kontogianni; Zan-Sheng Huang; Miguel A. Ariza-Prota; Nitesh Gupta; Manu Madan; Venkata Nagarjuna Maturu; Virender Pratibh Prasad; C. Steinack; Na Wu; Thomas Gaisl; Felix JF Herth; Ye Fan

doi:10.1080/25310429.2025.2593067

January 20, 2026PulmonologyOpen Access

Endobronchial ultrasound-guided mediastinal biopsies for the diagnosis of mediastinal diseases: A network meta-analysis

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Key Points

The research aims to determine the effectiveness of endobronchial ultrasound-guided biopsies for diagnosing mediastinal diseases.
Conducted a network meta-analysis of available studies on EBUS-guided biopsies.
Evaluated the effectiveness of EBUS-TBNA alone and in combination with cryobiopsy.
Assessed safety profiles across different biopsy techniques.
EBUS-TBNA was identified as the cornerstone diagnostic technique for mediastinal lesions.
EBUS-TBNA combined with cryobiopsy showed the highest effectiveness.
All evaluated EBUS-guided biopsies maintained a favorable safety profile.

Implication

Network meta-analysis reveals EBUS-TBNA's effectiveness in diagnosing mediastinal diseases, suggesting improved patient outcomes.

Abstract

EBUS-TBNA is the diagnostic cornerstone for mediastinal lesions, with EBUS-TBNA plus cryobiopsy being most effective. All EBUS-guided biopsies demonstrated a favourable safety profile.

Discussion

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Cite This Study

Qi et al. (2026) studied this question.

synapsesocial.com/papers/69730f78c8125b09b0d1f521 https://doi.org/10.1080/25310429.2025.2593067

View Full Paper

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Endobronchial ultrasound-guided mediastinal biopsies for the diagnosis of mediastinal diseases: A network meta-analysis

Key Points

Implication

Abstract

Discussion

Cite This Study

Endobronchial ultrasound-guided mediastinal biopsies for the diagnosis of mediastinal diseases: A network meta-analysis

Key Points

Implication

Abstract

Discussion

Cite This Study

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