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Elevated GDF-15 levels are linked to increased multimorbidity in people with HIV, suggesting its role as a clinical biomarker.
Elevated GDF-15 was consistently associated with multimorbidity in PWH, primarily driven by aging and tobacco smoking. GDF-15 appears to reflect a broader state of multisystem physiological stress than traditional endothelial activation markers, supporting its utility as a biomarker to identify PWH at higher risk of age-related comorbidities and to monitor the impact of modifiable risk factors in clinical care.
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López et al. (2026) studied this question.
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