Change in Growth Differentiation Factor 15 Concentrations over Time Independently Predicts Mortality in Community-Dwelling Elderly Individuals
Why the study?
Does GDF-15 concentration and its change over time predict all-cause mortality in community-dwelling elderly individuals?
Population
1,004 community-dwelling elderly individuals from the PIVUS study, evaluated at age 70 and age 75.
Design
Cohort
Follow-up
median 8.0 years
Authors
Discussion
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Member takes
Implication
May refine mortality prognostication in elderly adults; leaves open incremental value over standard risk factors.
Structured PICO
Does GDF-15 concentration and its change over time predict all-cause mortality in community-dwelling elderly individuals?
P
Population
1,004 community-dwelling elderly individuals from the PIVUS (Prospective Investigation of the Vasculature in Uppsala Seniors) study, evaluated at age 70 (n=1004) and age 75 (n=813).
I
Intervention
Measurement of Growth differentiation factor 15 (GDF-15) concentrations and their changes over a 5-year period.
O
Outcome
All-cause mortalityhard clinical
GDF-15 concentrations and their changes over a 5-year period independently predict all-cause mortality in community-dwelling elderly individuals, improving prognostic discrimination.
Cite This Study
Eggers et al. (2013) studied this question.