In vitro and murine model findings demonstrate ceftaroline-carbapenem restores efficacy against MRSA, indicating a promising treatment strategy.
The limited but rising threat of ceftaroline-resistant MRSA poses a therapeutic challenge. We show that ceftaroline plus carbapenems restores activity against a resistant strain both in vitro and in a murine bacteremia model. These findings support combination therapy as a potential strategy for difficult MRSA infections, warranting further clinical investigation.
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Olson et al. (2025) studied this question.
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