What question did this study set out to answer?

To evaluate the relationship between post-induction ustekinumab levels and clinical remission at week 26 in patients with inflammatory bowel disease.

January 23, 2026Journal of Crohn s and Colitis

P1020Association of Post-Induction Ustekinumab levels with treatment response in inflammatory bowel disease patients

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To evaluate the relationship between post-induction ustekinumab levels and clinical remission at week 26 in patients with inflammatory bowel disease.
Retrospective analysis from a tertiary IBD center
Measured serum UST trough concentrations post-induction and during maintenance
Collected demographic, clinical, and treatment data
Used descriptive statistics, t-tests/Mann–Whitney U tests, and logistic regression
Post-induction UST levels were significantly higher (7.62 μg/mL) than maintenance levels (1.86 μg/mL, p < 0.001)
Patients with fistulizing disease had a tendency towards lower UST levels
Clinical remission at week 26 was associated with higher post-induction UST levels (median 8.12 vs 4.62 μg/mL, p = 0.047)
Higher UST trough concentration was associated with an increased likelihood of remission (OR = 2.41, p = 0.076)

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Implication

Retrospective study finds higher post-induction ustekinumab levels correlate with clinical remission in inflammatory bowel disease, suggesting potential for treatment optimization.

Cite This Study

Kralj et al. (2026) studied this question.

synapsesocial.com/papers/69730fc4c8125b09b0d1f71a https://doi.org/10.1093/ecco-jcc/jjaf231.1201

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Implication

Retrospective study finds higher post-induction ustekinumab levels correlate with clinical remission in inflammatory bowel disease, suggesting potential for treatment optimization.

P1020Association of Post-Induction Ustekinumab levels with treatment response in inflammatory bowel disease patients

Key Points

Discussion

Implication

Cite This Study

P1020Association of Post-Induction Ustekinumab levels with treatment response in inflammatory bowel disease patients

Key Points

Discussion

Implication

Cite This Study

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