What question did this study set out to answer?

To analyze therapeutic sequencing strategies and identify difficult-to-treat cases in patients with inflammatory bowel disease (IBD) in a Mexican referral center.

January 23, 2026Journal of Crohn s and Colitis

P0739Therapeutic sequencing strategies and identification of difficult to treat cases in inflammatory bowel disease at a referral center in Mexico

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To analyze therapeutic sequencing strategies and identify difficult-to-treat cases in patients with inflammatory bowel disease (IBD) in a Mexican referral center.
Retrospective analysis of 298 IBD patient records
Categorization based on Montreal classification and therapeutic lines
Statistical analysis using SPSS v29 with Friedman’s test and Kaplan-Meier curves
Identification of patients with three or more therapeutic lines as difficult-to-treat
Five patients (29.4%) met criteria for difficult-to-treat IBD
Mean age of patients was 40.05 ± 15.29 years
Pancolitis was most common in ulcerative colitis (66.6%)
Ustekinumab showed the longest persistence as second-line treatment
Treatment persistence decreased with each subsequent therapeutic line, indicating increased refractoriness

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Implication

This observational study identifies treatment patterns in inflammatory bowel disease patients, indicating complex clinical cases may need advanced therapies.

Cite This Study

Lopez et al. (2026) studied this question.

synapsesocial.com/papers/69730fc4c8125b09b0d1f8e2 https://doi.org/10.1093/ecco-jcc/jjaf231.920

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Implication

This observational study identifies treatment patterns in inflammatory bowel disease patients, indicating complex clinical cases may need advanced therapies.

P0739Therapeutic sequencing strategies and identification of difficult to treat cases in inflammatory bowel disease at a referral center in Mexico

Key Points

Discussion

Implication

Cite This Study

P0739Therapeutic sequencing strategies and identification of difficult to treat cases in inflammatory bowel disease at a referral center in Mexico

Key Points

Discussion

Implication

Cite This Study

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