What question did this study set out to answer?

The aim is to create membranes that can differentiate between methylated and unmethylated peptides associated with the G9a protein.

January 23, 2026Open Access

Functionalized Two-Dimensional Nanochannel Membranes to Distinguish Methylated/Unmethylated Peptides for Sensing Cellular G9a Protein

Key Points

The aim is to create membranes that can differentiate between methylated and unmethylated peptides associated with the G9a protein.
Developed functionalized two-dimensional nanochannel membranes.
Conducted assessments of peptide binding and separation.
Analyzed binding affinities and specificity for methylation status.
Demonstrated successful differentiation of methylated and unmethylated peptides.
Achieved high sensitivity in detecting changes in peptide profiles related to G9a activity.

Abstract

Histone methyltransferase G9a-catalyzed histone modifications serve as critical epigenetic marks that regulate diverse cellular functions. Aberrant enzymatic activities of G9a are closely associated with various human pathologies making them as...

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Cite This Study

Hu et al. (Thu,) studied this question.

synapsesocial.com/papers/69730fe2c8125b09b0d1f911 https://doi.org/https://doi.org/10.1039/d5sc09089j

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