What question did this study set out to answer?

This research aims to compare drug concentration levels of infliximab in serum and tissue between subcutaneous and intravenous administration in patients with inflammatory bowel disease.

January 23, 2026Journal of Crohn s and Colitis

P0718Higher colonic tissue drug concentrations of subcutaneous compared to intravenous infliximab administration in patients with Inflammatory Bowel Disease

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This research aims to compare drug concentration levels of infliximab in serum and tissue between subcutaneous and intravenous administration in patients with inflammatory bowel disease.
Compared serum and tissue drug levels of infliximab in patients receiving SC and IV therapy.
Colonoscopy performed on all eligible participants to collect biopsy specimens and blood samples.
Clinical and endoscopic activity scores assessed to evaluate disease status.
Serum drug levels for SC were 22 µg/mL compared to 9 µg/mL for IV (p < 0.001).
Tissue drug levels for SC were 25 µg/g compared to 10 mg/g for IV (p = 0.002).
Tissue levels correlated positively with endoscopic activity in both cohorts (p < 0.001).
A serum infliximab level >16.1 mg/mL predicted tissue levels >14 mg/g with 94% sensitivity and specificity.

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Implication

This analysis compares drug levels between subcutaneous and intravenous infliximab in IBD, indicating potential for better treatment outcomes.

Cite This Study

Roblin et al. (2026) studied this question.

synapsesocial.com/papers/69730fe2c8125b09b0d1f926 https://doi.org/10.1093/ecco-jcc/jjaf231.899

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Implication

This analysis compares drug levels between subcutaneous and intravenous infliximab in IBD, indicating potential for better treatment outcomes.

P0718Higher colonic tissue drug concentrations of subcutaneous compared to intravenous infliximab administration in patients with Inflammatory Bowel Disease

Key Points

Discussion

Implication

Cite This Study

P0718Higher colonic tissue drug concentrations of subcutaneous compared to intravenous infliximab administration in patients with Inflammatory Bowel Disease

Key Points

Discussion

Implication

Cite This Study

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