P0443Long-term outcome of patients with Ulcerative Colitis after Ileal Pouch–Anal Anastomosis: the Latium NET study, preliminary data

Key Points

This research aims to assess the long-term pouchitis-free survival in ulcerative colitis patients who have undergone ileal pouch-anal anastomosis (IPAA).
Conducted retrospective multicenter study across 15 centers in the Latium Net.
Included patients who underwent IPAA with ileostomy closure from January 1980 to December 2024.
Analyzed clinical, demographic, treatment data, and follow-up of at least one year.
50% of patients experienced at least one episode of pouchitis within a median follow-up of 3.1 years.
Pouchitis-free survival at one year decreased from 92.54% to 64.65% across cohorts.
41.3% developed chronic pouchitis, with 82.7% of these requiring advanced therapy.

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Multicenter study evaluates long-term pouchitis outcomes in ulcerative colitis patients after IPAA, indicating declining survival rates.

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Cuccia et al. (2026) studied this question.

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