Evolutionary Aspect of Spike Glycoprotein's Conformational Dynamics

Wentao Xu; Tianyu Guo; Haibin Su

doi:10.1039/d5cp04391c

January 1, 2026Physical Chemistry Chemical Physics

Evolutionary Aspect of Spike Glycoprotein's Conformational Dynamics

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Key Points

This research explores how the spike glycoprotein's conformational changes affect SARS-CoV-2 infectivity.
Analyzed the RBD transition between closed and open states.
Utilized molecular dynamics simulations to capture dynamic changes.
Investigated the implications of these conformational shifts on viral infectivity.
Identified critical conformational states that influence the spike protein's function.
Demonstrated that transitions from closed to open states increase viral infectivity.

Implication

Evolutionary analysis of the spike protein's conformational transitions reveals insights on viral infectivity.

Abstract

The conformational transition of the RBD of the SARS-CoV-2 spike (S) protein from the “closed” to the “open” state is an important dynamic event influencing the infectivity of the virus....

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Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/69730fe2c8125b09b0d1fa2e https://doi.org/10.1039/d5cp04391c

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Evolutionary Aspect of Spike Glycoprotein's Conformational Dynamics

Key Points

Implication

Abstract

Discussion

Cite This Study

Evolutionary Aspect of Spike Glycoprotein's Conformational Dynamics

Key Points

Implication

Abstract

Discussion

Cite This Study

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