P1296 Impact of depression on health- related quality of life in Crohn’s disease patients-are we doing enough? A single tertiary center experience

Background Crohn’s disease (CD) is a chronic inflammatory bowel disease that significantly impacts patient’s health-related quality of life (HRQOL). Psychological factors such as anxiety, depression, and alexithymia may exacerbate these effects. This study aims to evaluate: HRQOL and possible factors affecting it, prevalence of anxiety, depression and alexytimia in patients with CD. Methods A cross-sectional study included 255 CD patients (139 males, mean age 39 ± 13). Data were collected using standardized self-administered questionnaires (socio-demographic, GAD-7, PHQ-9, TAS-20 and SIBDQ-10). Clinical data on remission status, extraintestinal manifestations, comorbidities and use of advanced therapies were also collected. Hierarchical regression analysis of variables predicting SIBDQ-10 score in CD was done. Results In our patients average disease duration was 10.4 ± 7.7 years (range 1-42). 177 patients (69.4%) were treated with advanced therapies. Clinical and laboratory remission was present in 239 (93.7%) patients. Prevalence of depression, anxiety and alexithymia were 53.7%, 43.2% and 38.4% respectively. There were no differences in PHQ-9, GAD-7 and TAS-20 scores in relation to remission status (p > 0.05). Average SIBDQ score was 54.9 ± 10.8. Patients in remission reported better SIBDQ-10 compared to symptomatic patients (p = 0.002). Results of hierarchical regression analysis showed that remission of disease and higher depression score significantly predict HRQOL in CD patients (p < 0.01). Conclusion Prevalence of depression, anxiety and alexithymia in CD patients is high, even if disease is in remission. Remission of disease and a high depression score are the main factors related to HRQOL. Conflict of interest: Dr. Jaksic, Dunja: No conflict of interest Vuksanovic, Sasa: No conflict of interest Toplicanin, Aleksandar: No conflict of interest Spirić, Jelena: No conflicts Popovic, Gorica: No conflict of interest Sokic Milutinovic, Aleksandra: No conflicts of interests