P1242Socioeconomic consequences of paediatric Inflammatory Bowel Disease: A population-based matched cohort study of patients and their siblings

Background Evidence of the socioeconomic consequences of pediatric-onset inflammatory bowel disease (IBD) is conflicting. A Norwegian study found children with IBD to have lower odds of completing upper secondary education,1 while a recent Danish study found the opposite.2 Thus, with unclear evidence regarding the socioeconomic consequences of paediatric-onset IBD, we investigated the socioeconomic impact of IBD on both patients and their siblings to study this hypothesis in the context of potential within a family. Methods We performed two matched cohort studies: one comparing socioeconomic outcomes of patients with paediatric-onset IBD born in Denmark between 1983-1994 to controls, and the other comparing socioeconomic outcomes of siblings of paediatric-onset IBD cases to controls. Study participants were identified using the Danish Civil Registrations System. Cases were matched 1:10 with controls on sex, year of birth, birth order, and municipality of residence at birth. Covariates included were household income, parental educational level, maternal labour market position prior to birth, and severity of IBD. Outcomes were evaluated at age 30 and included completion of secondary education, duration of completed education in years, and weeks not in the labour force between ages 29-30. Results In total, 1,482 paediatric-onset IBD patients, their 14,625 controls, 1,717 siblings of IBD patients, and their 16,893 controls were included in the study. IBD patients had the same mean probability of completing secondary education as controls (95% CI: -1.79 – 1.82), while siblings had a significantly higher mean probability than controls (95% CI: 1.33 – 4.68). Duration of education was the same between IBD patients and controls (95% CI: -0.12 – 0.13), while siblings had significantly longer educations (95% CI: 0.04 – 0.28). Finally, IBD patients had significantly more weeks not in labour force than controls (95% CI: 2.10 – 3.85), while siblings had fewer than controls (95% CI: -1.80 – -0.17). Conclusion We found no impact on socioeconomic achievements for patients at age 30 following paediatric-onset IBD; however, when compared to the unaffected siblings of paediatric-onset IBD patients, it appears that the IBD patient population possessed a higher potential for socioeconomic achievement which they were unable to fulfil. This study’s methods provide a unique perspective into potential socioeconomic factors influencing the conclusions of previous studies, which warrants further investigation. References: 1. Rasalingam A, Brekke I, Dahl E, Helseth S. Impact of growing up with somatic long-term health challenges on school completion, NEET status and disability pension: a population-based longitudinal study. BMC Public Health. 2021;21(1). doi:10.1186/S12889-021-10538-W 2. Rasmussen J, Nørgård BM, Nielsen RG, et al. Implication of Inflammatory Bowel Disease Diagnosed Before the Age of 18 for Achieving an Upper Secondary Education: A Nationwide Population-Based Cohort Study. Inflamm Bowel Dis. 2024;30(2):247-256. doi:10.1093/IBD/IZAD157 The authors declare that no AI tools were used in the analysis or writing of this abstract. Conflict of interest: Moran, Hunter: No conflicts of interest to declare. Lie, Mads: Nothing to declare. Vinkel Hansen, Anne: Anne Vinkel Hansen discloses no conflicts of interest Poulsen, Gry Juul: No conflicts of interest. Jess, Tine: Personal Fees: Consultancy for Ferring, Pfizer, Johnson&Johnson