Systematic review explores nutritional interventions that enhance wound healing in at-risk populations, suggesting personalized approaches.
Objectives To synthesize evidence on nutritional influences and interventions in wound healing, particularly in dermatology and at‐risk populations. Methods Systematic search of PubMed, Google Scholar, and other databases (2015–2025) using terms like “nutritional deficiencies,” “wound healing,” “dermatologic surgery,” “key nutrients,” and “supplementation.” Included English‐language peer‐reviewed articles, trials, reviews, and meta‐analyses on nutrient roles in healing phases and interventions (oral/topical supplementation, immunonutrition, emerging therapies). Narrative synthesis applied due to heterogeneity. Results From PubMed records, 63 studies included after screening. Key nutrients (protein; vitamins A, C, D, E; zinc, copper, iron) support immunity, collagen synthesis, angiogenesis, and re‐epithelialization. Deficiencies, common in elderly, diabetic, oncology, and surgical patients, delay healing and raise complications. Targeted interventions show benefits in Mohs surgery, burns, and keloid‐prone individuals. Screening tools and dietitian involvement recommended. Conclusions Nutrition is a modifiable factor optimizing wound outcomes. Personalized interventions reduce burden; further high‐quality trials needed.
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Pugliese et al. (2026) studied this question.
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