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Integrating residence time and binding affinity improves drug-target interactions, suggesting advancements in drug design.
Integrating residence time and traditional binding affinity provides a more comprehensive framework for understanding drug-target interactions and guiding rational drug design. Optimizing residence time can enhance pharmacodynamic efficacy, improve target selectivity, and enhance safety. Accordingly, residence time is emerging as a key kinetic parameter in modern drug discovery.
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Liu et al. (2026) studied this question.
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