P1302 Assessment of Extraintestinal Manifestations in Inflammatory Bowel Disease

Background Inflammatory bowel disease (IBD) extends beyond intestinal inflammation and frequently affects extraintestinal organs. These extraintestinal manifestations (EIMs) substantially reduce quality of life and may differ by sex.1,2 However, data on gender-specific distribution and the frequency of systemic symptoms such as fatigue and insomnia remain limited. This study aimed to evaluate EIM patterns among IBD patients, focusing on sex-related differences and the clinical importance of fatigue and sleep disturbance as underrecognized yet impactful symptoms. Methods A retrospective cross-sectional analysis was conducted on 404 IBD patients followed at a tertiary gastroenterology center. Demographic, clinical, and laboratory data were reviewed. EIMs were categorized as musculoskeletal, dermatologic, ocular, hepatobiliary, renal, hematologic, or constitutional. Sex-based and disease-type comparisons were made using Chi-square and Mann–Whitney U tests (p < 0.05). Employment status and disease duration were also analyzed to identify contextual associations. Results The cohort included 218 ulcerative colitis (54%), 180 crohn disease (44.6%), and 6 indetermine colitis (1.4%) patients, with a mean age of 41.6 ± 13.8 years. Females comprised 46.8% of the population. Overall, 65.8% of patients exhibited at least one EIM. Women showed higher frequencies of arthralgia (42.9%), whereas men presented more ankylosing spondylitis (15.3%), osteoporosis (28.2%) and nephrolithiasis (20.6%). Dermatologic findings such as eczema and erythema nodosum were also more frequent among females. Fatigue and insomnia were reported by over half of all patients (51–57%), not sex-dependent and nearly 88% of individuals identified fatigue as their primary limitation. Conclusion EIMs were detected in nearly two-thirds of IBD patients, revealing distinct gender-based and subtype-specific patterns. Artralgia and dermatologic involvement predominated among women, whereas men exhibited higher frequencies of ankylosing spondylitis, osteoporosis and nephrolithiasis. Despite not showing marked sex dependence, fatigue and insomnia were highly prevalent. Fatigue and insomnia emerge as crucial but often overlooked manifestations that substantially impair daily functioning. Routine assessment of these symptoms and sex-aware management strategies could improve the holistic management of IBD patients. References: 1. Alizadeh M, Motwani K, Siaton BC and et al. Factors Associated With Extraintestinal Manifestations of Inflammatory Bowel Disease in SPARC-IBD. Inflamm Bowel Dis. 2024; 30(11):2027-36. 2. Salem DA, El-Ijla R, AbuMusameh RR, and et al. Sex-related differences in profiles and clinical outcomes of Inflammatory bowel disease: a systematic review and meta-analysis. BMC Gastroenterol. 2024; 24(1):425. Conflict of interest: Akkoyun, Aytul: ıbd, extraintestinal manifestations Kara, Banu: No conflict of interest