Key result
Alzheimer's disease reveals 113 dysregulated genes with significant sex differences in expression versus healthy controls.
Why the study?
Women with Alzheimer's disease have higher prevalence and more severe dementia syndrome than men, and brain regions are affected differently, but the underlying mechanisms are poorly understood.
Population
Postmortem brain samples across 19 cortical regions of normal controls and individuals with dementia and neuropathology of AD
Comparison
Individuals with dementia and neuropathology of AD vs normal controls stratified by sex and brain region
Design
Differential gene expression analysis of a bulk tissue dataset with western blot validation
Authors
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Sex differences in Alzheimer's gene expression warrant stratified analyses; hypothesis-generating and should not yet change practice.
This study identifies sex- and brain region-specific gene expression dysregulation in Alzheimer's disease, highlighting potential novel mechanisms and targets for personalized treatment.
Wan et al. (2026) studied this question. In Alzheimer's disease, 113 dysregulated genes were identified, with 77 in women and 49 in men, indicating significant sex differences in gene expression.
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