High-Throughput Chiral Analysis Using Automated Desorption Electrospray Ionization Mass Spectrometry

Jie Li; Nicolás M Morato; Bo Hao; Ainslie Chen; Lucile Jouffroy; Ho Kim; Zhicai Shi; Karel Goossens; Iulia Ioana Strambeanu; R. Graham Cooks

doi:10.1039/d5cc06641g

January 1, 2026Chemical Communications

High-Throughput Chiral Analysis Using Automated Desorption Electrospray Ionization Mass Spectrometry

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Key Points

The research aims to enhance chiral analysis speed and efficiency in drug development using automated DESI-MS.
Implemented the kinetic method on the DESI-MS platform
Conducted automated separation-free chiral analysis
Focused on high-throughput experimentation in drug development
Achieved rapid analysis of chiral compounds
Demonstrated efficiency improvements in enantiomeric separation
Showed effective application in drug development contexts

Implication

Automated DESI-MS demonstrates rapid enantiomeric analysis in drug development, suggesting improved efficiency.

Abstract

Rapid chiral analysis is important for high-throughput experimentation in drug development. Here, we implement the so-called “kinetic method” on an automated DESI-MS platform for the fast and separation-free enantiomeric analysis...

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Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69731089c8125b09b0d2032e https://doi.org/10.1039/d5cc06641g

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High-Throughput Chiral Analysis Using Automated Desorption Electrospray Ionization Mass Spectrometry

Key Points

Implication

Abstract

Discussion

Cite This Study

High-Throughput Chiral Analysis Using Automated Desorption Electrospray Ionization Mass Spectrometry

Key Points

Implication

Abstract

Discussion

Cite This Study

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