What question did this study set out to answer?

This project aims to explore CD38 as a target to prevent intestinal fibrosis in Crohn’s disease.

Targeting CD38 for the prevention and treatment of Crohn’s disease-associated fibrosis

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Investigative project explores CD38's role in intestinal fibrosis, indicating potential new therapy for Crohn’s patients.

This project aims to explore CD38 as a target to prevent intestinal fibrosis in Crohn’s disease.
Evaluate CD38's role in driving fibroblast activation with NAD depletion using human intestinal fibroblasts.
Treat fibroblasts with CD38 inhibitor (78c) and measure fibrosis markers (COL1A1, ACTA2).
Analyze CD38 inhibition in two mouse models of Crohn’s-like ileitis and fibrosis.
Assess changes in gene expression through ileal transcriptomics.
Increased CD38 expression was observed in fibrotic regions of human CD specimens.
CD38 inhibition reduced fibroblast activation in both in vitro and in vivo models.
Anticipated results indicate that targeting CD38 could lower fibrosis progression, potentially improving patient outcomes.

Parigi et al. (2026) studied this question.

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